Quiescent (Q) State Instability and Translational Control in Breast Cancer Tumor Persistence
Biomedical Engineering
Aditya Misra
Abstract
My project investigates how tumor cells switch between dormant and actively dividing states (quiescence) using single-cell RNA sequencing data from breast cancer tumors. I analyze the data using computational tools in R to classify cells by their cell-cycle phase and measure how many quiescent-like cells are re-entering the cell cycle, particularly the S-phase where DNA replication occurs.
Understanding this transition can help reveal mechanisms that allow tumors to survive treatment and potentially lead to cancer recurrence.
