Opentrons Interfacing Turbidostat for Continuous Evolution
Biomedical Engineering
William Hack
Abstract
Surface Display for Phage Assisted Continuous Evolution (SurPhACE) enables the development of novel nanobodies with specific and heightened binding affinity to a given target. Automation of this method in one 96 well plate would enable 64x greater evolutionary speed compared to the previous manual method. My project developed a turbidostat to provide fresh bacteria to an Opentrons OT2 liquid handling robot, enabling automation of SurPhACE.
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